ASP2000 On-Line HPLC System

Fully Automated Dissolution Testing

A typical On-Line HPLC Tablet Dissolution Testing System is composed of:
PTWS310, manual or automated Tablet Drop Magazine, EPE Auto Sampling Manifold, PTFE  tubing installation, Peristaltic or Piston Pump, ASP2000 Sample Processing System, Agilent HP 1100 HPLC Pump and Multiple Wavelength Detector, the full system is controlled by the WinDiss32-V3 software (21CFR part 11 compliant) and a control PC system.
The perception of automation in dissolution testing differs greatly from user to user. The most labour intensive stage is taking samples at the specified time periods as found in the company SOP (Standard Operating Procedure). This involves the taking of 6 samples according to the USP and most other Pharmacopoeia, there is often a requirement for a staggered start in most cases so that accurately timed sampling may be achieved. At this point the operator must also consider either to remove samples manually and replacing the collected samples volumes in the dissolution vessels or use an automated system.
The WinDiss32-V3 software can be applied on-line to allow the control a PTA Dissolution Bath connected via the ASP2000 to a Chemstation* driven Agilent* HP1100 GC System. The WinDiss32-V3* software is 21CFR part 11 compliant and installed at a control PC system using Windows 2000*, XP* or NT* (*reg.TM)